Where to get materials and reagents you may ask? Buy for cheap off farmers in bulk or track Auction House lots. Get in touch with most big sellers. Communication is important here, send a whisper or write them a letter. It would be good for both of you to establish business relationships. Constant suppliers and buyers is convenient for both parties to save the time and effort.
Leatherworking has three specializations: Elemental, Tribal and Dragonscale. I’d pick up Tribal one. It allows to craft Devilsaur set items. Hunters, Rogues, Warriors, Feral Druids, even Enhancement Shamans and Retribution Paladins are among your potential clients. On any realm there is Un’Goro Mafia on Horde and Alliance, they control whole Un’Goro Crater zone and farm Devilsaurs 24/7. They are making thousands of gold. With Dragonscale Spec you are able to craft Black Dragon Mail set. Good demand as well among DPS classes Warriors, Hunters, Shamans, Paladins, for those who wants Bis Pre-Raid items fast and easy.